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DEXTROPROPOXYPHENE - A DRUG TO BE USED JUDICIOUSLY

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Author(s): Dr.Anil Batta

Journal: International Journal of Chemical Sciences and Research
ISSN 2249-0329

Volume: 01;
Issue: 05;
Start page: 34;
Date: 2011;
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Keywords: opioid | restless legs syndrome | ant arrhythmic | depression

ABSTRACT
Dextroprorpoxyphene is an analgesic in the opioids category. It is intended to treat mild pain and has, in addition, anti-tussive and local anesthetic effects. But analgesic, opioid withdrawal, RLS being major uses along with, anitussive, antidepressive, muscle cramps activity adverse overdose side effects are cardiac arrhythmias. Dextroprorpoxyphene is a weak opioid known to cause dependency among recreational users. It is ineffective for some individuals with the "poor metabolizer" genotype of the liver cytochromeP450 and enzyme CYP2D6. It does not have much effect on mental cravings; however it can be effective in alleviating physical withdrawal effects of opioids, such as muscle cramps. It is commonly used to ease the withdrawal symptoms in people addicted to opioids. Propoxyphene and its metabolite non-Propoxyphene have local anesthetic effects at concentrations about 10 times those necessary for opioids effects. It relieves the symptoms of restless legs syndrome (RLS). It also acts as a potent, noncompetitive neuronal receptor agonist as well as weak serotonine reuptake inhibitor. It has various side effects like Constipation, Itching, Drowsiness, Sore throat, Impaired alertness, Confusion, Serious or fatal heart rhythms. Owing to its positive causes, a Study was carried out during my stay at civil hospital at Lehragaga suburb in Sangrur district of Punjab, adverse and verse effects. Aim of the study was to have a judicious view to prescribe and use the drug for various disorders. Aim of the study was to compare the clinical findings in the patients taking Dextroprorpoxyphene and the patients taking routine drugs like non-opioid analgesics, depressed patients taking antidepressants like tricyclics antidepressants, patients of bronchitis taking antitussives without opioids like codine,athletes with cramps taking non-opioid antiinflammatory and analgesics. It was ensured that they are taking drugs having no relevance, mode of action and side effects similar to opioids.60 patients taking Dextroprorpoxyphene for therapeutic purposes suffering from various illness were selected for study .

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