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Diabetes type 2 and Alzheimer disease – one or twodiseases? Mechanisms of association

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Author(s): Małgorzata Marszałek

Journal: Postępy Higieny i Medycyny Doświadczalnej
ISSN 0032-5449

Volume: 67;
Issue: 863688;
Start page: 653;
Date: 2013;
Original page

Keywords: amyloidoses | fibrillation | Aβ peptide | amylin | Alzheimer Disease | diabetes mellitus type 2

ABSTRACT
Some epidemiological data and pathophysiological evidence suggest similarities and connectionof two amyloidoses: diabetes mellitus type 2, (DM2) (non-insulin dependent diabetes mellitus,NIDDM) and Alzheimer’s disease (AD). What they have in common is insulin resistance,neurodegeneration, development and progression of dementia, and the fact that in the courseof both diseases fibrillar aggregates of specific proteins are accumulated in affected organs.What is more, experimental evidence also supports the hypothesis that small prefibrillar aggregatesthat emerge prior to the appearance of mature fibrils are responsible for a key stepin development and cytotoxicity of both diseases. They also have similar pathogenic effects.Both peptides possess the common receptor AMY3. More and more evidence is accumulatingthat key cell regulation processes are similar for both diseases as well. The question is raised:can Alzheimer be a new form of diabetes disease?

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