Academic Journals Database
Disseminating quality controlled scientific knowledge

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

ADD TO MY LIST
 
Author(s): Goldberg Jonathan M | Manning Gerard | Liu Allen | Fey Petra | Pilcher Karen E | Xu Yanji | Smith Janet L

Journal: PLoS Genetics
ISSN 1553-7390

Volume: 2;
Issue: 3;
Start page: e38;
Date: 2006;
Original page

ABSTRACT
Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced Drosophila. It contains members of most kinase classes shared by fungi and metazoans, as well as many previously thought to be metazoan specific, indicating that they have been secondarily lost from the fungal lineage. This includes the entire tyrosine kinase-like (TKL) group, which is expanded in Dictyostelium and includes several novel receptor kinases. Dictyostelium lacks tyrosine kinase group kinases, and most tyrosine phosphorylation appears to be mediated by TKL kinases. About half of Dictyostelium kinases occur in subfamilies not present in yeast or metazoa, suggesting that protein kinases have played key roles in the adaptation of Dictyostelium to its habitat. This study offers insights into kinase evolution and provides a focus for signaling analysis in this system.
RPA Switzerland

RPA Switzerland

Robotic process automation

    

Tango Rapperswil
Tango Rapperswil