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DIFFERENCES IN THE HISTAMINE-INDUCED WEAL AND FLARE INHIBITION BETWEEN CETIRIZINE AND LORATADINE

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Author(s): Kastriot Shytaj | Leonard Deda | Petrit Bara | Edi Grabocka | Ervin Marku | Gezim Boçari

Journal: Pharmacologyonline
ISSN 1827-8620

Volume: 3;
Issue: 3;
Start page: 6;
Date: 2012;
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Keywords: Cetirizine | Loratadine | histamine | histamine H1 antagonists | skin tests.

ABSTRACT
Background: Different studies demonstrate superiority of Cetirizine over Loratadine in the suppression of flare reactions caused by Epicutaneus Skin Prick Test with Histamine (ESPTH) but there are contradictory evidences regarding their effect on the weal reactions. This study aimed to compare these superiorities.Method: Loratadine 10 mg and Cetirizine 10 mg were given to 26 volunteers in a double-blind, randomized cross-over method. The subjects performed the ESPTH immediately before the medications were administered,and then 30 minutes, 1, 3, 5, 6 and 24 hours after they received the drugs. Twenty minutes after each ESPTH, flare and weal were drawn into a transparent paper. After four weeks the subgroups changed the drugs and underwent the same procedure.To analyze the differences between flare and weal, we carefully cut the transparent paper tracings and weighed them in an analytical weighing-machine. The differences were analyzed with Wilcoxon Signed Ranks Test.Results: Cetirizine was more effective on inhibiting the flare (at 3, 5, 8 and 24 h post-dosing) and the weal (at 3, 5 and 8 h post-dosing) than Loratadine (p
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