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Dissolution Enhancement of Ibuprofen Solid Dispersion Prepared with Vinyl Polymers by Fusion Method

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Author(s): Naz Hasan Huda | Nadia Saffoon | Yeakuty Marzan Jhanker

Journal: Stamford Journal of Pharmaceutical Sciences
ISSN 1999-7108

Volume: 3;
Issue: 2;
Start page: 7;
Date: 2010;
Original page

Keywords: Ibuprofen | Dissolution rate | Solid dispersion | Fusion method | Kollidone | Povidone

ABSTRACT
Solid dispersions of ibuprofen are prepared by the fusion method aiming to enhance its dissolution properties. Three vinyl polymers named Kollidone VA64, Povidone K12 and Povidone K30, are used in this work. In vitro dissolution studies were carried out to evaluate the dispersions. The outcome of the study indicated that the rate of dissolution of ibuprofen was considerably improved when formulated in solid dispersions with Povidone K12 and Povidone K30. Solid dispersions with Kollidone VA64 showed drug retarding capability and can be used to formulate sustained release dosage form.
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