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Does erythropoietin slow progression of chronic kidney disease?

Author(s): Nasri Hamid | Ghorbani Ali

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 2;
Start page: 81;
Date: 2013;
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Keywords: Erythropoietin | Erythropoiesis | Kidney protection | Chronic kidney disease

Implication for health policy/practice/research/medical education:The initiation of erythropoietin therapy for the purpose of renoprotection may need to be sooner than that for erythropoiesis, because erythropoietin may attenuate renal fibrosis through macrophage adjustment and endothelial cell protection by other uncertain mechanisms. Although, agents re-establishing the initial function of renal erythropoietin-producing cells could defer kidney fibrosis, however more studies should be carried out to determine the cellular target of erythropoietin in kidney and developinga new erythropoietin derivative for renal care.

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