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Dopamine Transporter Density by [99mTc]-TRODAT-1 SPECT and Neurocognitive Performance - a preliminary pilot study.

Author(s): Shih, Ming C. MD. | Amaro, Edson Jr. MD, PhD. | Souza, Sayuri de E | Pupo, Mariana C. | Malta, Stella M. MPhi. | Hoexter, Marcelo Q. MD. | Garrido, Griselda J. PhD. | Bueno, Orlando A. PhD. | Ferraz, Henrique MD, PhD. | Goulart, Fabricio O. MD. | Wagner, Jairo MD. | Lin, Li F. PhD. | Fu, Ying K. PhD. | Lacerda, Acioly T. MD, PhD. | Bressan, Rodrigo A. MD, PhD.

Journal: Alasbimn Journal
ISSN 0717-4055

Volume: 8;
Issue: 33;
Date: 2006;
Original page

Keywords: Neuropsychological Assessment | Parkinson Disease | TRODAT-1 | SPECT.

Introduction: Cognitive deficits are associated with functional impairment as well as with poor quality of life in Parkinson’s disease (PD). The main brain alteration in PD is a progressive loss of nigrostriatal dopamine neurons. Both animal and human studies have demonstrated that basal ganglia dopamine system is important for cognitive and motor functioning. Dopamine transporter (DAT) PET and SPECT radiotracers have been successfully used to estimate, in vivo, dopamine neuronal loss in humans.Objectives: The present study is aimed to examine the relationship between cognitive impairment and striatal dopamine neuronal loss, as estimated by [99mTc]-TRODAT-1 SPECT in PD patients.Methods: Fifteen PD patients were scanned with [99mTc]-TRODAT-1 SPECT (Dual-Head-SPECT Hwakeye, GE). SPECT images were reconstructed with FBP and Butterworth filter 0,40c/px order 10. Regions of interest (ROIs) were striatum (STR) and occipital lobe (BKG nonspecific binding) and were delineated in 3-mm transaxials slices analyzed according to this formula BP=([STR-BKG]/BKG), where BP is the striatal DAT binding potential. Neurocognitive tests, including the Rey Auditory Verbal Learning Test, Wisconsin Card Sorting Test, Ravens Progressive Matrices, Digit Span and Tavis 3, were applied to all subjects by trained neuropsychologists.Results: Striatal DAT binding potential (BP) was negatively correlated with the RAVLT tests 4 (R= 0.57, p
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