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Eccrine Angiomatous Hamartoma: A Retrospective Study of 15 Cases

Author(s): Yi-Ting Lin | Chien-Ming Chen | Chih-Hsun Yang | Yea-Huey Chuang

Journal: Chang Gung Medical Journal
ISSN 2072-0939

Volume: 35;
Issue: 02;
Start page: 167;
Date: 2012;
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Keywords: eccrine angiomatous hamartoma | sweat gland tumor | hamartoma | hemangioma | ultrasonography

Background: Eccrine angiomatous hamartoma (EAH) comprises a rare nevoid proliferation of normal eccrine glands and small blood vessels and occasionally otherelements in the middle and deep dermis with variable clinical manifestations.Case series have rarely been published except for case reports and literaturereviews. The aims of this article were to investigate the clinical and pathologic features of patients with EAH in Taiwan and to compare our resultswith the results of previous studies.Methods: A retrospective review of medical records and histopathological findings wasperformed on patients diagnosed with EAH in a medical center in Taiwanbetween 1994 and 2010.Results: Fifteen patients with pathologically diagnosed EAH were collected. Themean age at the time of diagnosis was 38.6 years (range, birth to 67 years).The male to female ratio was 3 to 2. In most cases, EAH arose as a singlelesion on a lower extremity. The symptoms and signs most commonly associated with EAH were pain (60%), hypertrichosis (13.3%), itching (13.3%)and hyperhidrosis (6.7%). Additional pathological findings included hemangioma (13.3%), verrucous hemangioma (6.7%), arteriovenous malformation(6.7%), and angiokeratoma (6.7%). None of the patients experienced spontaneous regression of the lesions before excision. Excisions were done in onepatient under general anesthesia, and ten patients with local anesthesia. Fourpatients were kept under observation. Tumor recurrences were noted in twoout of the eleven patients whose lesions were excised.Conclusion: Compared with cases in the literature, we found additional histopathologicalfindings and an increased tumor recurrence risk in our cohort. EAH remainsa benign and uncommon hamartomatous condition. Further multi-center, retrospective studies with larger case numbers are needed to better characterizethe disease presentation in Asian populations.
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