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Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats

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Author(s): Esmaeal Tamaddonfard | Amir Erfanparast | Nasrin Hamzeh-Gooshchi | Shahnaz Yousofizadeh

Journal: Avicenna Journal of Phytomedicine
ISSN 2228-7930

Volume: 2;
Issue: 4;
Start page: 196;
Date: 2012;
Original page

Keywords: Curcumin | Diazepam | Penicillin-Induced Seizures | Rats

ABSTRACT
Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats.Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings.Results: Intraperitoneal (i.p.) injections of curcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p
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