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Effect of Dialysis on Heme Oxygenase-1 (HO-1) Expression in Peripheral Blood Leukocytes of End Staged Renal Diseased Patients

Author(s): Sathyapriya Kandavelu | Parameswari Chetenchery Somasundaram

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 5;
Start page: 416;
Date: 2011;
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Keywords: renal failure | leukocytes | dialysis | Heme oxygenase | reactive oxygen species | flow cytometry

-1. About 20 samples were collected from predialysis patients, 22 samples were collected from patients undergoing dialysis and 22 samples were collected from post dialysis patients. The samples were subjected to antioxidant enzyme analysis followed by flow cytometric and immunoflouroscence studies HO-1 expression was found to be elevated in all the dialysis conditions but higher elevation was observed in post dialysis patients. The results suggest that HO-1 might have some link with the disease progression and though upregulated like other stress proteins, its antioxidant capacity has been ineffective to cease the disease invasion.]]>
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