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Effect of Different Biological Membranes on In Vitro Bioadhesion Property

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Author(s): Maswadeh M Hamzah*, Kanaan A Reem**, Aljarbou N Ahmad* and Al-Hanbali A Othman***

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 2;
Start page: 155;
Date: 2010;
Original page

Keywords: Bioadhesion | Carbopol | Polyvinylpyrrolidone | Chicken pouch | Sodium carboxymethylcellulose.

ABSTRACT
The influence of biological membranes on in vitro bioadhesion property of Carbopol 934P (CP), Polyvinylpyrrolidone (PVP K90) and sodium carboxymethylcellulose (Cekol 10,000) was studied using a texture analyzer equipment. Polymer/biological membrane interaction was significantly influenced by the contact time used during the study. An increase in contact time also increased bioadhesion strength. An intermediate contact time of 180s was deemed to be the most suitable contact time. In addition, different polymers produced different values of bioadhesion strength. Moreover, polymer molecular weight is directly correlated with bioadhesion strength. Biological membrane, such as rabbit gastric mucosa, cow intestine, pig intestine or chicken pouch, is a less significant determinant in affecting the bioadhesion strength as compared to the type of polymer used. Chicken pouch, an easily available and uniform tissue, offers an attractive alternative to be employed as a model biological membrane in bioadhesion study.
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