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Effect of DRD2/ANKK1 taqIA allelic polymorphism on the risk and prognosis of cervical precancer and cancer

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Author(s): József Cseh | Zsuzsa Orsós | Emese Pázsit | Erika Marek | András Huszár | István Ember | István Kiss

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 4;
Start page: 25;
Date: 2012;
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Keywords: Cervical Cancer | Precancer | DRD2 | Polymorphism | HPV

ABSTRACT
Objectives: The aim of this study was to elucidate the role of dopamine receptor D2 / ankyrin repeat and protein kinasedomain containing 1 (DRD2/ANKK1) TaqIA allelic polymorphism in the HPVinduced cervical carcinogenesis. Methods:1. Effect on the risk of cervical precancer: After an 8yearfollowup, out of 214 women with persisting highriskHPV infection, 102 developed highgrade cervical dysplasia or cervical intraepithelial neoplasia (CIN) grade III, while 112 did not. The subjects were genotyped for the DRD2/ANKK1 TaqIA polymorphism by PCRRFLP, and the allelic distributions were compared between groups with and without highgrade dysplasia. 2. Prognostic value: Two hundred and thirty nine women with cervical precancer/cancer were followed for 5 years. Complete remission was achieved at 182 women. Toassess the prognostic value of the TaqIA polymorphism, genotype frequencies were compared between patients reaching and not reaching complete remission. Results: The frequency of A1/A1+A1/A2 genotypes was higher among women who developed highgradecervical dysplasia (OR: 1.87, 95% CI: 1.053.33; p=0.034) than in the other group. Occurrence of the A1 allele was more frequent among women who did not reach complete remission (OR: 2.00, 95% CI:1.073.74; p=0.030) than in women with complete remission. Conclusions: This is the first report on the possibleinvolvement of DRD2/ANKK1 TaqIA polymorphism in cervical carcinogenesis. The A1 allele seems to increase the riskof cervical precancer, and it may also be associated with a worse prognosis in women with HPVinducedcervical cancer. The results need further validation in largescalemolecular epidemiological studies.
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