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Effect of methotrexate on persistent ectopic pregnancy after conservative laparoscopic surgery

Author(s): Li-an LI | Yan-qin YOU | Ling-yun HU | Ke HUANG | Xiao-yu FU | Wen YANG

Journal: Medical Journal of Chinese People's Liberation Army
ISSN 0577-7402

Volume: 38;
Issue: 5;
Start page: 409;
Date: 2013;
Original page

Keywords: pregnancy | tubal | pregnancy | ectopic | laparoscopy | methotrexate

Objective  To analysis the effect of methotrexate (MTX) on the occurrence of persistent ectopic pregnacy (PEP) after conservative laparoscopic surgery. Methods  The clinical data of 124 patients with ectopic pregnancy who underwent conservative laparoscopic surgery conservative from 2005 to 2012 were analyzed retrospectively. 124 patients were divided into MTX group (n=92) and non-MTX group (n=32). In MTX group, 40 cases were injected MTX 25mg in mesosalpinx, 52 cases were injected 50mg/m2 intramuscular. Results  Seven cases of PEP was diagnosed in each group. The difference between the two groups was statistically significant (χ2=4.825, P=0.028). In MTX group, there was no statistically significant between local injection and systemic administration (χ2=0.576, P=0.448). Conclusions  Prophylactic use of MTX can reduce the incidence of PEP after conservative laparoscopic surgery.

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