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Effect of Sub-Acute Intravenous Injection of Endothelin Receptor Agonist IRL-1620 in Mice

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Author(s): M. Chaudhary | R. Sehgal | P. Arora | N. Kharb

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 5;
Issue: 4;
Start page: 222;
Date: 2010;
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Keywords: ET1 | ETB | IRL-1620 | Endothelin | toxicity

ABSTRACT
B receptor agonist IRL-1620 in mice. Swiss albino mice (n = 24, weighing 20-25 g) were divided into two groups (12 animal each), control group (0 g kg-1) and IRL-1620 treated group (1 g/kg/min, i.v., for 30 days). Each group was further subdivided into two groups depending on sex of mice having 6 animals each. No significant change in animal body weight, hemogram, liver function test and renal function tests was observed on treatment with IRL-1620. Histological examination of liver was normal and Kidneys showed mild congestion. In conclusion, sub-acute dose (1 g/kg/min, i.v.,) of endothelin receptor agonist ETB IRL-1620 did not cause toxic effect on liver and kidney.]]>
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