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Effects of β2-adrenergic receptor polymorphisms on asthma severity and response to salbutamol in Egyptian children

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Author(s): Khaled Saalah | Saed Morsy | Amal Atta

Journal: Egyptian Journal of Pediatric Allergy and Immunology
ISSN 1687-1642

Volume: 10;
Issue: 2;
Start page: 81;
Date: 2012;
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Keywords: Polymorphism | β2-adrenergic receptor (ADRB2) gene | asthma | Egyptian children | bronchodilator therapy

ABSTRACT
Background: Several polymorphisms of the β2-adrenergic receptor (ADRB2) gene have been identified. There is mounting evidence that these polymorphisms are associated with significant variability in response to bronchodilator therapy and thus in severity and duration of asthmatic symptoms. Objectives: to assess the frequency of ADRB2 polymorphisms at codon 16 in Egyptian asthmatic children and to study the association of these polymorphisms with asthma severity and response to inhaled salbutamol. Methods: This case-control study was conducted at pulmonology unit, Zagazig University children’s hospital during the period from December 2010 to December 2011. One hundred children (50 asthmatics and 50 controls) were enrolled into the study. For all study population, detailed history taking, systematic physical examination, chest x-ray, pulmonary function testing and ADRB2 genotyping were performed. Results: There was a significant increase in frequencies of Arg/Gly and Gly/Gly genotypes among asthmatic children in comparison with healthy controls (OR = 7.9; CI: 0.94-67.4, P
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