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Effects of MnTnHex-2-PyP on markers of inflammation and lipid peroxidation in asthma mice model

Author(s): Veneta SHOPOVA | Lyudmil TERZIEV | Violeta DANCHEVA | Galya STAVREVA | Milena ATANASOVA | Angelina STOYANOVA | Tzvetan LUKANOV

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 2;
Start page: 24;
Date: 2011;
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Keywords: Asthma | BALF | Inflammation | Lipid Peroxidation | Lung Homogenate | MnTnHex-2-PyP

Background and objective: Investigation of the effects of MnTnHex-2-PyP on some markers of inflammation and lipidperoxidation in an asthma mice model.Methods: The experiment was carried out on 24 female mice C57Bl/6, divided into four groups: group 1, controls; group 2,injected with ovalbumin (OVA); group 3, treated with MnTnHex-2-PyP and group 4, treated with OVA and MnTnHex-2-PyP.The animals from groups 1 and 3 were injected i.p. on days 0 and 14 with a 100 μl phosphate-buffered saline (PBS), and those from groups 2 and 4 were injected with a 100 μl ovalbumin solution, containing 20 μg OVA. On days 24, 25 and 26 the mice from groups 1 and 2 were inhaled with PBS for 30 min, and those from groups 2 and 4 were given a 1% ovalbumin solution. One hour before inhalation, and 12 hours later the animals from groups 1 and 2 were injected i.p. with 100 μlPBS, and those from groups 3 and 4 received a 100 μl MnTnHex-2-Pyp solution in PBS сontaining 0.05mg/kg.Results: Ovalbumin alone (group 2) increased the total cell number, total protein content, the levels of IL-4, IL-5 and8-isoprostane in bronchoalveolar lavage. Elevations were observed in IgE level in serum, and the malone dialdehyde (MDA) content in the lung homogenate. These markers were decreased significantly in group 4 as compared to the OVA group.Conclusions: MnTnHex-2-Pyp reduces the inflammation and lipid peroxidation in Ovalbumin-induced mice asthma model.
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