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Effects of X-ray on postnatal body weight,growth of skin and hair,activities and content of Superoxide dismutase,Catalase,and Maleic dialdehyde in liver and kidney in mice

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Author(s): DENG Hai-Ping | YU Shi-Yuan | CHEN Yu-Qin | WANG Yu | GUO Ting-Ting | FENG Hong-Li | JIA Yan-Fang

Journal: Acta Zoologica Sinica
ISSN 0001-7302

Volume: 54;
Issue: 6;
Start page: 1029;
Date: 2008;
Original page

Keywords: X-rays | Filial Mice | Weight | Skin | SOD | MDA | CAT

ABSTRACT
To explore the dynamic changes of body weight,skin and activities of antioxidant-enzyme in liver and kidney of developing filial mice after irradiation with different dosages of X-ray,provide a basis for prevention and cure of irradiation,the effect of different dosages (0.0,0.5,2.0,3.5,5.0,6.5 Gy) of X-ray on activity and content of Superoxide dismutase(SOD),Catalase (CAT),and Maleic dialdehyde (MDA) in liver and kidney of developing filial mice(1 d,5 d,10 d,20 d) were determined by colorimetry. The results showed that the body weight of filial mice decreased after irradiation with 2.0、3.5、5.0 and 6.5 Gy of X-ray. Skins started to be denuded of hairs 3 d after irradiation with 3.5,5.0 and 6.5 Gy of X-ray but the new hairs resurged at 10 d. Purple spot appeared in the skin of 6.5 Gy group filial mice. SOD activity in 0.5 Gy group filial mice increased in the early time after irradiation,subsequently decreased to the normal level gradually. In other groups,SOD activity decreased firstly and then increased slowly,but it was always lower than the control group. MDA content in 0.5 Gy group filial mice decreased in the early time,then increased to the normal level slowly. In other groups,it obviously increased firstly and then decreased slowly,but always higher than the control group. CAT activity in 0.5,2.0 Gy groups filial mice decreased in the early time,then increased. However,in other groups the activity increased in the early time and decreased in the following days. There was a trend that the activity and content of target enzyme in liver and kidney recovered slowly to the normal level after irradiation. The irradiation of X-rays affects the weight,skin and activity of antioxidant-enzyme in liver and kidney of developing filial mice significantly. And the dosages contributed more to the damage effect than treatment time. In short, large dosages of irradiation would cause disadvantageous effect on developing filial mice[Acta Zoologica Sinica 54(6): 1029 – 1037, 2008].
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