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Efficacy of Cynodon dactylon for immunomodulatory activity

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Author(s): R.Santhi*and S.Annapoorani1

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 2;
Start page: 112;
Date: 2010;
Original page

Keywords: Cdpf (Cynodon dactylon protein fraction) | HAT (Haemagglutinating Antibody Titre) | DTH (Delayed Type Hypersensitivity) | NI (Neutrophil Index) | CMI (Cell mediated Immunity).

ABSTRACT
Cynodon dactylon (Poaceae) commonly known as arugampul, is a perennial grass, forming thick mats by means of stolons and rhizomes. It is bitter, sharp, hot taste, good odour, laxative, brain and heart tonic, emetic, expectorant, carminative and useful against pains, inflammation and tooth ache. In the present study an attempt has been made to evaluate Cynodon dactylon protein fraction immunomodulatory activity. Cynodon dactylon protein (Cdpf) was administered intraperitonealy at doses of ED50 to healthy Swiss albino mice. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Intraperitonealy administered Cdpf showed a significant increase of test parameters Viz., neutrophil test, Haemagglutinating Antibody Titre (HAT) and Delayed Type Hypersensitivity (DTH) response. In mice immunized with sheep RBC, Cdpf enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the food pad thickness response to sheep RBC in sensitized mice. There was increase in immunomodulation, there was significant improvement compared to control group and differences were statistically significant in Cdpf, therefore Cynodon dactylon protein fraction promises strong utility in clinical practice as an effective immunostimulant.

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