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Endocrinology of testicular descent and hormonal therapy in cryptorchidism

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Author(s): Mollaiyan M

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 8;
Issue: 31-32;
Start page: 102;
Date: 1998;
Original page

ABSTRACT
The mystery of testicular descent remains a challenge for urological research. In this article the impressive investigational output in recent years, especially the role of mullerian inhibitory substance and the genito-femoral nerve, are reviewed. It is currently suggested that hypogonadotropic hypogonadism plays a more central; role. How this interacts in the complex process of testicular descent remains to be investigated. Testicular biopsies in cryptorchidism demonstrate histologic depletion of germ cells and leydig cells in undescended testicle, as well as in the contralateral descended testis in many cases. European use LHRH and HCG for assisting scrotal positioning of "Almost" descended testes, while north American investigators use HCG, but not LHRH hormone, to reveal retractile testes.
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