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Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen

Author(s): Wan-Xia Wu | Hai-Yang Wang | Na Wang | Wei-Wei Zhang | Han Lai | Xiao-Qi Yu

Journal: Polymers
ISSN 2073-4360

Volume: 5;
Issue: 3;
Start page: 1158;
Date: 2013;
Original page

Keywords: enzymatic synthesis | CAL-B | thermosensitive polyester | ketoprofen | PEG

Three linear polyesters with pendant ketoprofen were synthesized by copolymerization of polyethylene glycol (PEG) with malic acid (thiomalic acid or aspartic acid) using lipase B acrylic resin from Candida antarctica (CAL-B) at 90 °C respectively. These thermosensitive polyesters exhibit a lower critical solution temperature (LCST) at 10–12 °C. The in vitro study demonstrated that these polyesters could release ketoprofen in neutral and alkaline medium but showed hydrolytic stability in acid medium. These results suggest that, with pendant drugs, these thermosensitive polyesters have potential applications in biomedical materials.
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