Academic Journals Database
Disseminating quality controlled scientific knowledge

The Epicardium and Coronary Artery Formation

ADD TO MY LIST
 
Author(s): Adriana A. S. Pires-Gomes | José M. Pérez-Pomares

Journal: Journal of Developmental Biology
ISSN 2221-3759

Volume: 1;
Issue: 3;
Start page: 186;
Date: 2013;
Original page

Keywords: coronary artery | embryo | heart vascularization

ABSTRACT
The coronary system is the network of blood vessels that nourishes the heart muscle. After birth, proper coronary blood circulation is required to support heart homeostasis, and altered coronary function frequently leads to myocardial ischemia, infarction and heart failure. The epicardium plays a pivotal role during coronary blood vessel embryonic development, contributing cells to the coronary vasculature, but also secreting diffusible signals that regulate coronary morphogenesis and secondarily impact on ventricular compact myocardium growth. Accordingly, anomalous epicardium development gives rise to the multiple congenital defects of the coronary vascular system and the heart walls. In this review, we will summarize and discuss our current knowledge on the embryogenesis of coronary blood vessels, as related to epicardial development, and attempt to highlight the biomedical relevance of this tissue.
RPA Switzerland

RPA Switzerland

Robotic process automation

    

Tango Jona
Tangokurs Rapperswil-Jona