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The Epidemiology of Sarcoma

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Author(s): Burningham Zachary | Hashibe Mia | Spector Logan | Schiffman Joshua D

Journal: Clinical Sarcoma Research
ISSN 2045-3329

Volume: 2;
Issue: 1;
Start page: 14;
Date: 2012;
Original page

ABSTRACT
Abstract Sarcomas account for over 20% of all pediatric solid malignant cancers and less than 1% of all adult solid malignant cancers. The vast majority of diagnosed sarcomas will be soft tissue sarcomas, while malignant bone tumors make up just over 10% of sarcomas. The risks for sarcoma are not well-understood. We evaluated the existing literature on the epidemiology and etiology of sarcoma. Risks for sarcoma development can be divided into environmental exposures, genetic susceptibility, and an interaction between the two. HIV-positive individuals are at an increased risk for Kaposi’s sarcoma, even though HHV8 is the causative virus. Radiation exposure from radiotherapy has been strongly associated with secondary sarcoma development in certain cancer patients. In fact, the risk of malignant bone tumors increases as the cumulative dose of radiation to the bone increases (p for trend
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