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Evaluating ranitidine, pantoprazole and placebo on gastric pH in elective surgery

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Author(s): Bhattacharyya Tapas | Sarbapalli Debabrata | Pal Ranabir | Sarkar Ujjal | Kar Sumit | Kundu Kanak | Zaman Forhad

Journal: Saudi Journal of Anaesthesia
ISSN 1658-354X

Volume: 5;
Issue: 1;
Start page: 67;
Date: 2011;
Original page

Keywords: Pantoprazole | preoperative | ranitidine

ABSTRACT
Background and Aim: Concern about the grim nature of postoperative acid aspiration syndrome grew among the anesthesiologist over the years warranting the need for pre-emptive intervention. The aim of the study is to compare the effects of preoperative oral ranitidine versus pantoprazole given in regulating gastric pH in elective surgery. Methods: This prospective, parallel group, controlled, randomized, single-blind study was conducted at a tertiary care postgraduate teaching institute at Kolkata, involving 120 participants of either sex, aged 18-60 years of American Society of Anesthesiologists physical status I and II, who were scheduled for elective surgery under general anesthesia lasting for more than 2 h. The participants were divided into three groups. In group A (n=40) participants received placebo tablet, in group B (n=40) participants received ranitidine tablet while in group C (n=40), participants received pantoprazole tablet and their gastric pH estimated serially. Results: The participants in the three groups were comparable in terms of age, sex, body weight, duration of surgery and type of surgery distribution. In regard to changes in gastric pH trends, there was no statistically significant difference between serial pH values in group A (Friedman test; P>0.05) and group C participants. (P>0.05). However, the mean preoperative gastric pH values (7.140±.7652) were significantly lower than mean pH values (7.253±.7514) after 2 h postoperatively in group B participants (P
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