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Evaluation of analgesic activity of methanolic extract of Trapa natans l.var. Bispinosa

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Author(s): Anuj k. Agrahari, Mohd. Khaliquzzama and Sanjaya k. Panda

Journal: Journal of Current Pharmaceutical Research
ISSN 0976-3171

Volume: 1;
Issue: 1;
Start page: 8;
Date: 2010;
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Keywords: Trapa bispinosa roots | Floating Herb | Methanol Extract | Analgesic activity | Tail flick method | Tail immersion test | Pentazocine.

ABSTRACT
Objective: The main objective of the present investigation is to evaluate the analgesic activity of methanolic extract of Trapa natans L.var. bispinosa Roxb. roots on mice.Materials & Methods: Analgesic activity of the methanolic extract of the T. bispinosa root at a dose of 200mg/kg & 400mg/kg was evaluated against the standard drug pentazocine at a dose of 30mg/kg. Adult Swiss albino mice of either sex of six numbers in each group was undertaken for study and evaluated by tail flick & tail immersion method.Results: The both doses of T. bispinosa roots methanolic extract was found to produce significant (p < 0.01) analgesic activity. In tail flick method, the extract at 200mg/kg showed significant activity (P
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