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EVALUATION OF ANEUPLOIDOGENIC POTENTIAL OF ANTINEOPLASIC TAXOL DEMONSTRATED ON DIPLOID STRAINS OF Aspergillus nidulans.

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Author(s): Simone Jurema Ruggeri Chiuchetta, Cynthia Priscilla do Nascimento Bonato e Cláudia Regina Sharan

Journal: SaBios : Revista de Saúde e Biologia
ISSN 1980-0002

Volume: 1;
Issue: 1;
Start page: 31;
Date: 2006;
Original page

ABSTRACT
Taxol is a drug isolated from the rind of Taxus brevifolia plant. In eukaryotic cells this drug, used as a chimiotherapic agent, hyper stabilizes the microtubules by its association with beta-tubulin protein. Cell becomes incapable to use cytoskeleton in a flexible way. Thus, it blocks the cellular cycle and modifies the normal segregation of chromosomes during mitoses. In this research, a diploid strain of Aspergillus nidulans fungus was used to evaluate the aneuploidogenic potential of taxol, as well as the toxicities of this drug. The results have demonstrated that taxol, in concentrations of 0,06mM and 0,18mM, is capable to induce aneuploidy.
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