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Evaluation of anti-inflammatory potential of Trigonella foenum-graecum (Fenugreek) seed extracts by using carrageenan induced rat paw edema

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Author(s): Kapil G. Malviya1,*, Mukesh W. Babhulkar2, Prashant Y. Mali3 and Vinod D. Rangari4

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 2;
Start page: 109;
Date: 2010;
Original page

Keywords: Anti-inflammatory potential | Carrageenan | Trigonella foenum- graecum (TFG) | Fenugreek | Seeds | Digital Vernier Caliper.

ABSTRACT
The aim of this study was to evaluate the anti-inflammatory potential of Trigonella foenum – graecum (TFG) seed extracts by using carrageenan induced rat paw edema in comparison to established anti-inflammatory drug diclofenac potassium (DIP, 10 mg/kg, p.o.). Successively extracted (aqueous and ethanol) extracts of TFG seeds were administered 1 h prior to inflammation induction in dose range of 50, 100 and 200mg/kg orally. The rat paw edema was induced by injecting 0.1 ml of 1 % w/v carrageenan solution, prepared with normal saline in sub-plantar region of left hind paw of the rats.Results of these study revealed that the ethanol extract at dose 200 mg/kg shows significant (p
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