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Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats

Author(s): Ghulam Moinuddin | Kshama Devi | Deepak Kumar Khajuria

Journal: Avicenna Journal of Phytomedicine
ISSN 2228-7930

Volume: 2;
Issue: 2;
Start page: 72;
Date: 2012;
Original page

Keywords: Antidepressant activity | Imipramine | Myristica fragrans

Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS).Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS.
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