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EVALUATION OF ANTIOXIDANT, ANALGESIC AND ANTIDIARRHOEAL ACTIVITY OF FLACOURTIA JANGOMAS (LOUR.) RAEUSCH. LEAVES

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Author(s): Chinmoy Talukder | Sanjib Saha1 | Suraj Adhikari | Hemonta Kumar Mondal | Khirul Islam | Anisuzzman

Journal: Pharmacologyonline
ISSN 1827-8620

Volume: 3;
Issue: 3;
Start page: 20;
Date: 2012;
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Keywords: Flacourtia jangomas | 1 | 1-Diphenyl-2-pycrylhydrazyl (DPPH) | Folin Ciocalteu’s reagent | reducing power assay | analgesic activity | antidiarrhoeal activity

ABSTRACT
In the present study, ethanol extract of leaves of Flacourtia jangomas was pharmacologically investigated to explore and evaluate the analgesic, antioxidant and antidiarrhoeal activities to provide a suitable lead,which may be utilized in future to pursue a new line of investigation. The extract exhibited a significant inhibition of DPPH radical scavenging activity in concentration dependent manner with IC50 value of 11 μg/mL whereas the IC50 value for the standard ascorbic acid was 5 μg/mL. Total phenol content of the extract was601.03 mg GAE/100 g of dried plant material measured by Folin Ciocalteu’s reagent. In reducing power assay,the extract revealed strong ferric reducing power in concentration dependent manner as compared with standard ascorbic acid; which was substantiated by high absorbance increased with the concentration. In acetic acid-induced writhing test, the extract (250 and 500 mg/kg) exhibited significant (p < 0.001) inhibition of writhing reflex in dose dependent manner; which was strongly comparable to the standard drug diclofenacsodium. Pain threshold level was appreciably raised in dose dependent manner by the extract in hot-plate test and results were statistically significant (p < 0.001). In in vivo antidiarrhoeal test, castor oil induced diarrhoeal model was utilized in which the extract (250 and 500 mg/kg) increased onset of diarrhoea and decreased the total number of stools as compared with the control in significant (p < 0.001) and dose dependent manner. Above results of the present study explored that the extract has some potential bioactivities which demand further investigations like LC-MS to isolate bioactive compounds and to identify underlying mechanisms.
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