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Evaluation of Antioxidant and Antinociceptive Properties of Methanolic Extract of Clerodendrum viscosum Vent.

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Author(s): Md. Mostafizur Rahman, | Nowshin N. Rumzhum | Kudrat-E-Khuda Zinna

Journal: Stamford Journal of Pharmaceutical Sciences
ISSN 1999-7108

Volume: 4;
Issue: 1;
Start page: 74;
Date: 2011;
Original page

Keywords: Clerodendrum viscosum | Verbenaceae | Antioxidant | Ascorbic acid | Antinociceptive | Swiss albino mice

ABSTRACT
The methanolic extract of Clerodendrum viscosum Vent. (Verbenaceae) was evaluated for in vitro antioxidant activity by determination of total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in swiss albino mice. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard and a dose-dependent (250 and 500 mg/kg) analgesic effect in Clerodendrum viscosum. The antioxidant and antinociceptive activities obtained seem to be in good accordance with the traditional uses of Clerodendrum viscosum.
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