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Evaluation of antitrypanosomal activity of Adansonia digitata (methanol seed extract) in Albino mice

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Author(s): Hassan Maina Ibrahim | Ogbadoyi O Emmanuel | Adamu Yusuf Kabiru | Maimuna Umar Bello | Yemisi Illumi

Journal: Scientific Journal of Veterinary Advances
ISSN 2322-1879

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2013;
Original page

Keywords: Trypanosomiasis | Anti-trypansomal | Intraperitoneally | Parasitaemia

ABSTRACT
Adansonia digitata, a shrub used in traditional medicine for the treatment of cancer was investigated for the treatment of experimental trypanosomiasis. Methanol seed extracts of the seed of Adansonia digitata was investigated for in-vivo anti-trypanosomal activity in albino mice infected with Trypanosoma brucei brucei and treated intraperitoneally with the extracts 24 hours post infection, at doses ranging from 50-500mg/kg for 14 days. The parasitaemia in each mouse was monitored including the control group which were treated with the standard drug; berenil. Seed extracts at dose of 400mg/kg showed significant antitrypanosomal activity (P

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