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Evaluation of binding properties of Moringa oleifera gum in the formulation of paracetamol tablets

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Author(s): M.R.Shivalingam*1, K.S.G Arul Kumaran2, Y.V.Kishore Reddy1, D.Jeslin2, M.Tejaswini1, Ch.MadhusudhanaRao1, B.SaiChaitanya1

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 69;
Date: 2010;
Original page

Keywords: Moringa oleifera | Binding concentration | dissolution | hardness | Paracetamol tablets

ABSTRACT
Plant gums and mucilage are being used in Pharmaceuticals and in other various industries due to their abundance in nature, safety and low cost. Binding agents are used to impart the structural strength required during the processing, handling and packaging of tablets. In view of the importance of binders in pharmaceuticals for the manufacture of tablets and capsules, gum isolated from the stem of Moringa oleifera have been evaluated for its binding properties in the formulation of conventional Paracetamol tablet (500mg) containing 8%, 10% and 12% binding concentration. The binding property of gum was evaluated in relation to conventional binder like gelatin at different parameter like percentage of fines, tablet hardness, disintegration time, dissolution and friability. Studies showed that increase in binding concentration of M.oleifera gum from 8% to 12% decreases the percentage of fine, increases the hardness, increases the disintegration time, decreases the percentage of friability and decreases % cumulative release. The binder-excipients interaction study was also carried out by using FTIR i.e. by KBr pellet method which showed that M.oleifera gum is compatible with drug and all excipients in the formulation. It may be concluded from the studies that increase in binding concentration decreases drug release hence this gum can be used to formulate sustained/controlled release tablet formulation, since it shows better tabletting characteristics have high potential for the substitution of expensive binder.
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