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Evaluation of the wound healing potential of Malvastrum tricuspidatum leaves

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Author(s): Neelam Balekar | Pankaj Dixit | Dinesh Kumar Jain | Vikramsingh Dange

Journal: Topclass Journal of Herbal Medicine
ISSN 2315-8840

Volume: 2;
Issue: 10;
Start page: 228;
Date: 2013;
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Keywords: Malvastrum tricuspidatum | excision wound | incision wound | dead space wound | hydroxyproline content

ABSTRACT
The present study was performed to substantiate the traditional claim of the wound healing activity of leaves of Malvastrum tricuspidatum in rats. The effect of aqueous and ethanolic extracts of leaves of M. tricuspidatum (5% and 10% w/v topically and 250 mg/kg and 500 mg/kg p.o.) on excision, incision and dead space wound model were examined. The healing of wound was assessed by the rate of wound contraction, period of epithelialization, tensile strength, dry granulation tissue weight, hydroxyproline content and histopathology of the granulation tissue. Treatment of wound with ethanolic extract 10% w/v topically exhibited significant (p < 0.01) wound healing activity in all three models. High rate of wound contraction, decrease in period of epithelialization, high tensile strength, increase in dry granulation tissue weight, elevated hydroxyproline content and increased collagenation in histopathological section were observed in animals treated topically with 10% w/v ethanolic leaf extract. The ethanolic and aqueous extracts were quantitatively analyzed for alkaloids, flavonoids and phenols and the contents were found to be greater in ethanolic than aqueous extracts. Topical application (10% w/v) of ethanolic extract possesses better wound healing property and this activity could be attributed due to presence of alkaloids, phenols and flavonoids
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