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Evolution of Biologics Screening Technologies

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Author(s): Peter Cariuk | Matthew J. Gardener | Tristan J. Vaughan

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 6;
Issue: 5;
Start page: 681;
Date: 2013;
Original page

Keywords: high throughput screening | assay technologies | therapeutic antibodies

ABSTRACT
Screening for biologics, in particular antibody drugs, has evolved significantly over the last 20 years. Initially, the screening processes and technologies from many years experience with small molecules were adopted and modified to suit the needs of biologics discovery. Since then, antibody drug discovery has matured significantly and is today investing earlier in new technologies that commercial suppliers are now developing specifically to meet the growing needs of large molecule screening. Here, we review the evolution of screening and automation technologies employed in antibody discovery and highlight the benefits that these changes have brought.
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