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Expression and significance of caspase-8 in chronic hepatitis

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Author(s): YANG Haifeng

Journal: Journal of Clinical Hepatology
ISSN 1001-5256

Volume: 29;
Issue: 2;
Start page: 138;
Date: 2013;
Original page

Keywords: caspase 8 | hepatitis | chronic | apoptosis

ABSTRACT
ObjectiveTo investigate the roles and mechanisms of the apoptosis effector molecule caspase-8 in the pathogeneses of chronic hepatitis B (CHB), chronic hepatitis C (CHC), and non-alcoholic steatohepatitis (NASH). MethodsCaspase-8 protein expression was examined by immunohistochemistry in liver biopsy samples from 70 patients with CHB, 50 patients with CHC, 50 patients with NASH, and 15 healthy controls. Histological analysis was performed to grade extent of inflammation and fibrosis. Apoptosis was detected by TUNEL assay. The significance of intergroup differences were assessed by Chi-squared test or Fisher’s exact test, and correlation was assessed by Spearman’s rank correlation coefficient. ResultsCaspase-8 expression was significantly higher in CHB (58.6%), CHC (64.0%), and NASH (82.0%) liver tissues than in healthy control liver tissues (13.3%) (all P<0.05). The increased caspase-8 expression was closely related to liver cell apoptosis (r=0.409, P<0.001). Moreover, the rate of caspase-8 detection was positively correlated with extent of pathological injury (P>0.05). ConclusionCaspase-8-mediated apoptosis of liver cells may play an important role in the pathogeneses of hepatitis diseases.

Tango Jona
Tangokurs Rapperswil-Jona

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