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Extraction of Penicillin V from Simulated Fermentation Broth by Liquid-Liquid Membrane Technique

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Author(s): Khalid W. Hameed

Journal: Al-Khawarizmi Engineering Journal
ISSN 1818-1171

Volume: 8;
Issue: 2;
Start page: 77;
Date: 2012;
Original page

Keywords: Liquid-liquid membrane | Penicillin V | pertraction | extraction.

ABSTRACT
Liquid-liquid membrane extraction technique, pertraction, using three types of solvents (methyl isobutyl ketone, n-butyl acetate, and n-amyl acetate) was used for recovery of penicillin V from simulated fermentation broth under various operating conditions of pH value (4-6) for feed and (6-8) for receiver phase, time (0-40 min), and agitation speed (300-500 rpm) in a batch laboratory unit system. The optimum conditions for extraction were at pH of 4 for feed, and 8 for receiver phase, rotation speed of 500 rpm, time of 40 min, and solvent of MIBK as membrane, where more than 98% of penicillin was extracted.

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