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FACTORS ASSOCIATED WITH MORTALITY AMONG PATIENTS WITH CENTRAL VENOUS CATHETER-RELATED BLOODSTREAM INFECTION IN AN INTENSIVE CARE UNIT

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Author(s): Priscilla Roberta Silva Rocha | Marcelo de Oliveira Maia | Gisele Brocco Magnan | Juliano Carregaro | Francisco de Assis Rocha Neves | Angelica Amorim Amato

Journal: American Journal of Infectious Diseases
ISSN 1553-6203

Volume: 8;
Issue: 4;
Start page: 175;
Date: 2012;
Original page

Keywords: Bloodstream Infection | Central Venous Catheter | Intensive Care Unit | Mortality

ABSTRACT
Central venous catheterization is a common practice in the management of critically ill patients and is associated with various complications, such as Bloodstream Infections (BSI), which are major determinants of increased morbidity, mortality and healthcare expenses. Few studies have addressed factors that predict mortality in patients with this complication. The aim of this study was to investigate factors associated with mortality in patients with Central Venous Catheter (CVC)-related BSI in an intensive care unit of a tertiary care hospital in the Federal District, Brazil. This was a retrospective and observational study, in which all CVC-related BSI that occurred between January 2008 and December 2010 were reviewed. We obtained demographic, clinical, biochemical and microbiological data from medical records and investigated its association with mortality during ICU stay. There were 4,504 ICU admissions during the study period and 68 were complicated by CVC-related BSI (4.09 per 1000 catheter-days), most due to gram-negative organisms (45.6%). Overall mortality was 59.7%. Death risk was significantly associated with mechanical ventilation (OR 27.8, 95% CI 3.28-250, p
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