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Factors associated with outcome after combined steroid and orbital radiotherapy on Graves’ ophthalmopathy

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Author(s): Kenji Moriyama | Kimiko Matsuda | Hiroshi Arai | Takashi Akamizu | Tetsuya Tagami | Kazuwa Nakao

Journal: Endocrinology Studies
ISSN 2038-9515

Volume: 3;
Issue: 1;
Start page: e6;
Date: 2013;
Original page

Keywords: intravenous steroid pulse therapy | thyroid | ophthalmometry

ABSTRACT
In order to seek possible confounding factors in relation to clinical responsiveness to high-dose intravenous steroid pulse therapy and orbital irradiation followed by oral steroids in the treatment of thyroid-associated ophthalmopathy (TAO), we reviewed the medical records of 53 admitted patients (22 men and 31 women out of a total pool of 167 patients who had diagnosis of TAO). To assess the improvement TAO, we employed proptosis as an objective index and followed up longitudinally. The final ratios of improvement in the left and right eyes respectively were 71.0% and 64.5%. Significant difference in the therapeutic effect on proptosis was found between male and female at the end of observation. The decrease in proptosis was significantly greater in female patients than in male patients (P
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