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Farmakogenomika leków przeciwdepresyjnych

Author(s): Joanna Hauser

Journal: Neuropsychiatria i Neuropsychologia
ISSN 1896-6764

Volume: 1;
Issue: 1;
Start page: 43;
Date: 2006;
Original page

Keywords: temperament | 5-HTT | DAT1 | DRD4 | polymorphism

Genetic factors are believed to play a major role in thevariation of treatment response and the incidence ofadverse effects of medications. Pharmacogenetics isconcerned with the role of genetic factors in predictingdrug response and adverse effects. This requires someknowledge of either the drug’s pharmacokinetic orpharmacodynamic profile so that candidate genes can bestudied. Considering the hypothesis for the mechanismof action of antidepressants, most pharmacogeneticstudies have concentrated on polymorphisms in genesinvolved in the serotonergic and noradrenergic system.Many studies have reported an association between theresponse to SSRI and 5-HTTLPR polymorphism. Theaim of pharmacogenomic is to study the relationshipbetween whole genome factors including the expressedtranscriptome and proteome and drug response. It ishoped that pharmacogenomic studies will lead to theprediction of response to antidepressants and reductionof adverse effects.

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