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Flavonoids from Macaranga lowii

Author(s): Widiastuti Agustina | Lia D. Juliawaty | Euis H. Hakim | Yana Maolana Syah

Journal: ITB Journal of Science
ISSN 1978-3043

Volume: 44;
Issue: 1;
Start page: 13;
Date: 2012;
Original page

Keywords: acasetin | cytotoxicity | isoprenylated dihydroflavonol | macaranga lowii | macalowiniin | 4’-O-methyl-8-isoprenylnaringenin | P-388 cells.

new isoprenylated dihydroflavonol derivative, macalowiinin (1), together with two known flavonoids 4’-O-methyl-8-isoprenylnaringenin (2) and 4’-O-methyl-5,7,4’-trihydroxyflavone (3) (= acasetin), have been isolated from the methanol extract of the leaves of Macaranga lowii. The structures of these compounds were determined based on UV, NMR, and mass spectral data, and optical rotation. Preliminary cytotoxic evaluation of compounds 1 – 3 against P-388 cells showed that compound 3 is the most active with IC50 was 58.7 mM.

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