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FORMULATION AND EVALUATION OF FLOATING TABLETS OF RHCL USING NATURAL AND SYNTHETIC POLYMERS

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Author(s): Sudhir Kumar Yadav

Journal: Pharma Research
ISSN 0975-8216

Volume: 03;
Issue: 01;
Start page: 221;
Date: 2010;
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Keywords: RHCL | GASTRORETENTIVE | FLOATING DRUG DELIVERY | SUSTAINED RELEASE

ABSTRACT
The present study involved development and characterization of newer floating tablets of Ranitidine hydrochloride by direct compression method using two different natural polymers like- Xanthan and Guar gum. Powders were evaluated for angle of repose, loose bulk density, tapped density, Carr’s index and Hausner ratio whereas the prepared tablets were evaluated for weight variation, thickness and diameter, hardness, friability, drug content, floating lag time, total floating time, hydration behavior, and in vitro dissolution study. The drug release kinetic was fitted in three different mathematical models like- Zero order, Higuchi and Korsmeyer-Peppas model. The results indicate that the drug release mechanism was found fickian diffusion type in most of the formulations. The developed floating tablets of Ranitidine hydrochloride may be used in clinic for prolonged drug release for at least 12h, thereby improving the bioavailability and patient compliance.
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