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Formulation and evaluation of Orodispersible tablets of terbutaline sulphate

Author(s): Margret Chandira .R., *Jaykar .B.,Chakrabarty B. L.

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 31;
Date: 2010;
Original page

Keywords: Terbutaline sulphate | direct compression | Orodispersible tablets | ac di sol | sod.cmc | alginic acid | chitosan.

Terbutaline sulphate is widely used medicine of bronchial asthma. It is a beta 2 receptor agonist. Orodispersible tablets of Terbutaline sulphate were prepared using superdisintegrants, ac di sol, sod.cmc, alginic acid, chitosan, mcc, as diluents by direct compression method. Twelve formulations were prepared using the superdisintegrants at lower, intermediate, higher concentration. Mannitol is used to enhance the organoleptic properties of tablets. Tablets were evaluated for uniformity of wt, hardness, friability, content uniformity, wetting time, dispersion time, disintegration time and in vitro drug release. All the formulation s showed disintegration time less than less than 35 and drug release by dissolution (100% at the end of 10 mins).
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