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Generation and characterization of an Advillin-Cre driver mouse line

Author(s): Zurborg Sandra | Piszczek Agnieszka | Martínez Conception | Hublitz Philip | Al Banchaabouchi Mumna | Moreira Pedro | Perlas Emerald | Heppenstall Paul

Journal: Molecular Pain
ISSN 1744-8069

Volume: 7;
Issue: 1;
Start page: 66;
Date: 2011;
Original page

Abstract Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.

Tango Rapperswil
Tango Rapperswil

RPA Switzerland

RPA Switzerland

Robotic process automation