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GLYCOLIC ACID AS A NOVEL AND GREEN SOLVENT FOR THE PREPARATION OF 3, 4-DIHYDROPYRIMIDIN-2(1H)-ONES Glykolsäure als eine neuartige und GREEN Lösungsmittel für die Herstellung Von 3, 4-dihydropyrimidin-2 (1H)-one.

Author(s): Neda Seyedi

Journal: Heterocyclic Letters
ISSN 2231-3087

Volume: 3;
Issue: 2;
Start page: 213;
Date: 2013;
Original page

Keywords: Multicomponent | Biginelli | 3 | 4-dihydropyrimidin | Glycolic acid.

Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H)-one derivatives. This synthesis was performed using glycolic acid as a green acidic solvent. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields and simple procedure.
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