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Growth hormone administration in the treatment of growth retardation in juvenile SLE - case history --- Leczenie hormonem wzrostu zaburzeń wzrastania w przebiegu młodzieńczego tocznia układowego - opis przypadku

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Author(s): Mirosława Urban | Maria Gardziejczyk | Anna Górska

Journal: Pediatric Endocrinology, Diabetes and Metabolism
ISSN 1234-625X

Volume: 13;
Issue: 3;
Start page: 171;
Date: 2007;
Original page

ABSTRACT
Introduction: A chronic autoimmune inflammatory process and a long-term steroid therapy seems to underlie growth inhibition in children suffering from juvenile systemic lupus erythematosus (JSLE).The study objective was to assess the effect of one-year GH therapy on the growth rate in a 17-year-old girl with JSLE diagnosed when she was 11. Case description: Growth rate slowdown was observed when the girl was eleven (up to the age of 10 the growth was harmonious - 50 centile). Since then, the mean gain in body height was approximately 1 cm/year. At the age of 16 (prior to the start of GH therapy), she was 148 cm high (below 3 centile), telarche II°, pubarche I°. The skeletal age corresponded to approximately 11 years according to the method of Greulich-Pyle. The girl under-went hormonal examinations in the Endocrinology Outpatient Department, including stimulatory tests of pituitary GH reserve, and based on the fin-dings she was qualified for GH therapy, at a weekly dose of 30 IU. Within the 6-month-therapy, the patient grew by 7.5 cm, with the final outcome of 161 cm. The period of treatment was free of JSLE exacerbations or glucose tolerance disturbances. The only side effects included enhanced thirst and transitory oedema of the lower extremities observed in the first week of therapy. At the same time the patient's general feeling improved. Conclusions: During a one-year GH therapy, the girl achieved catch-up growth, which was accompanied by body weight reduction and no significant side effects.

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