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Herpes Simplex Type I Infection and Atopy Association in Turkish Children with Asthma and Allergic Rhinitis

Author(s): Mahir Igde | Fusun Artiran Igde | Zafer Yazici

Journal: Iranian Journal Of Allergy, Asthma and Immunology
ISSN 1735-1502

Volume: 8;
Issue: 3;
Start page: 149;
Date: 2009;
Original page

Keywords: Atopy | Asthma | Herpesvirus-1

This study investigated the association between HSV-1 infection and atopy by comparing seropositivity to HSV-1 in atopic children with asthma and allergic rhinitis and in non-atopic children.Totally 249 children randomly selected from the university outpatient pediatric clinics were prospectively enrolled in the study between September 1 and November 30, 2007. Serum samples were examined using the virus neutralization test (VNT) for HSV-1 Immunoglobulin G(IgG) seropositivity. Skin prick tests (SPTs) were performed to determine atopic status. The results showed that HSV-1 IgG seropositivity was significantly higher in atopic children (56.8%) with asthma and allergic rhinitis than in the age-matched non-atopic children group (30.4%) (p
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