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Herpes simplex virus and varicella zoster virus, the house guests who never leave

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Author(s): Kinchington Paul R | Leger Anthony J St | Guedon Jean-Marc G | Hendricks Robert L

Journal: Herpesviridae
ISSN 2042-4280

Volume: 3;
Issue: 1;
Start page: 5;
Date: 2012;
Original page

Keywords: Alphaherpesvirus | Herpes Simplex Virus | HSV | Varicella Zoster Virus | VZV | Immunity | Pathogenesis

ABSTRACT
Abstract Human alphaherpesviruses including herpes simplex viruses (HSV-1, HSV-2) and varicella zoster virus (VZV) establish persistent latent infection in sensory neurons for the life of the host. All three viruses have the potential to reactivate causing recurrent disease. Regardless of the homology between the different virus strains, the three viruses are characterized by varying pathologies. This review will highlight the differences in infection pattern, immune response, and pathogenesis associated with HSV-1 and VZV.
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