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Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

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Author(s): Seng Koon Lim | Hans-Peter de Hoog | Atul N. Parikh | Madhavan Nallani | Bo Liedberg

Journal: Polymers
ISSN 2073-4360

Volume: 5;
Issue: 3;
Start page: 1102;
Date: 2013;
Original page

Keywords: polymersomes | hybrid vesicles | self-assembly | drug-delivery | soft matter

ABSTRACT
Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadiene-b-poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.

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