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Hypoglycemic effect of the Rhizophora Mangle Cortex on STZ-NAInduced Diabetic Rats

Author(s): Adolfo Andrade-Cetto | María Luisa Rubalcaba Mares

Journal: Pharmacologyonline
ISSN 1827-8620

Volume: 3;
Issue: 3;
Start page: 1;
Date: 2012;
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Keywords: Type 2 diabetes | hypoglycemic agent | medicinal plant | Rhizophora mangle.

This study sought to confirm the hypoglycemic effects of two extracts of the plant Rhizophora mangle(RM) in nicotinamide-streptozotocin induced diabetic rats (STZ-NA). RM is traditionally used in Mexico totreat type 2 diabetes, (T2D). Two different RM extracts were prepared and tested. The first extract was a water extract (WE), similar to the traditionally used tea, and the second extract was an ethanol:water extract (EWE). The extracts (WE 5.9 and 59 mg/kg, and EWE 9 and 90 mg/kg) were tested on STZ-NA rats to determine whether hypoglycemia occurred after administration of the extracts. Phytochemistry- Two different extracts were prepared, n-hexane and buthanol, to test for the presence of alkaloids, terpenes and phenolic compounds. The extracts that were administered to the STZ-NA-induced diabetic rats produced a significant hypoglycemic effect compared with the control group, similar to that achieved with glibenclamide. We also determinedthat phenolic compounds were the main components of the RM cortex.Diabetic people living near the Mexican coastal zones use the cortex of the Rhizophora mangle plant to treat type 2 diabetes. The results presented here support that extracts of this plant have hypoglycemiceffects, which is in agreement with the traditional use.
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