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Identification, synthesis and spectral characterization of impurities in process development of Escitalopram

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Author(s): Srinivas Gangula, Naveen Kumar Kolla, Chandrashekar R. Elati, Ashok. Dongamanti, Rakeshwar Bandichhor

Journal: GERF Bulletin of Biosciences
ISSN 2229-6433

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2011;
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Keywords: Escitalopram | impurities | spectroscopy | identification | characterization and synthesis

ABSTRACT
Synthesis and identification of five process-related impurities of escitalopram are described. Structures of all the four impurities were identified by employing LC-MS (liquid chromatography-mass spectrometry) and subsequently characterized by other spectral techniques e.g. IR and NMR. Based on the spectral data, the structures of these impurities were characterized as 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide 4, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxylicacid 5, N-{3-[5-cyano-1-(4-fluorophenyl)]-1,3-dihydro-2-benzofuran-1-yl]propyl}formamide 6 and 1-(4-fluorophenyl)-1-[3-(methyl amino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile 7.
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