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Immediate Type Drug Hypersensitivity Reactions and Associated Risk Factors in an Adult Turkish Men Population

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Author(s): Emel Kurt | Ahmet Ugur Demir | Omer Cadirci

Journal: Iranian Journal Of Allergy, Asthma and Immunology
ISSN 1735-1502

Volume: 9;
Issue: 4;
Start page: 245;
Date: 2010;
Original page

Keywords: Drug Allergy | Epidemiology | Hypersensitivity | Risk Factors

ABSTRACT
The study aimed to assess the prevalence and associated risk factors of immediate-type hypersensitivity reactions (HRs) to drugs in workers.The data consisted of 1152 questionnaires obtained from adult men that consisted of questions on HRs induced by drugs. The prevalence of self-reported drug HRs was 3.6% for all reactions. HRs were most common to beta-lactam antibiotics (51.2%) followed by nonsteroid antiinflammatory drugs (NSAIDs) (41.5%). Multivariate analysis showed that family atopy was associated with drug HRs to both antibiotics (Odds Ratio (OR) 95% Confidence Interval (CI) (3.32 (1.15-9.56)) and NSAIDs (3.70 (1.09-12.51)). Drug HRs of any type were associated with atopic family history (3.23 (1.43-7.24)), ever asthma diagnosis (2.74 (1.07-7.02)), ever allergic rhinitis (2.70 (1.25-5.84)), and ever eczema (3.80 (1.55-9.30)). Drug related skin manifestations were associated with family history of atopic diseases (4.07 (1.76-9.41)), ever allergic rhinitis (2.84 (1.24-6.5)), ever asthma diagnosis (3.16 (1.19-8.39)), and ever eczema diagnosis (4.59 (1.82-11.57)). Systemic manifestations of drug HRs were associated with only asthma diagnosis (4.66 (1.25-17.41)).Risk groups should be followed closely as candidates for immediate type HRs to antibiotics and NSAIDs in also relatively healthy and young aged adult men.
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